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KMID : 0616120070380030258
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 3 p.258 ~ p.262
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Phenolic Compounds from Capsiccum annuum Leaves Showing Radical Scavenging Effect
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Choi Jang-Gi
Park Jong-Cheol
Hur Jong-Moon
Jo Hyun-Woo
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Abstract
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In the present study, we investigated the antioxidant activity of methanol extract and its organic fractions (n-hexane, CH2Cl2, EtOAc, n-BuOH and H2O) of Capsiccum annuum leaves against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. As results, methanol extract, and its ethyl acetate and n-butanol fractions showed good scavenging effect at 100 μg/ml. Four compounds were isolated from the ethyl acetate fraction through silica gel and Sephadex LH-20 column chromatographies. Their chemical structures were elucidated as apigenin (1), vanillic acid (2), uracil (3) and apigenin 7-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside (4) by comparison of spectral data with those in reference. IC50 value of compound 2 was 14.7 μg/ml, while compounds 1, 3 and 4 had no effect on the DPPH radical.
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KEYWORD
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Capsiccum annuum, vanillic acid, antioxidant, DPPH
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